2021 – current position | Ocular Genomics Institute, Mass Eye and Ear, Harvard Medical School.
Director of the iPS Research Lab at the Ocular Genomics Institute of the Mass Eye and Ear.
Appointed Instructor of Ophthalmology, Harvard Medical School
TODO: complete with field, Projet, and responsabilities info.
2019 – 2021 | Institut des Neurosciences de Montpellier, France
Posdoctoral Researcher | Supervisor: Dr. Vasiliki Kalatzis
Gene Therapy of inherited retinal diseases due to large causative genes
Project
- Validation of a large capacity vector for retinal delivery of genes with large cDNA sequences
- Viral-mediated gene delivery in human photoreceptors and RPE cells derived from hiPSCs
Personnel under my supervision:
- Carla JIMENEZ, MSc student Erasmus plus fellowship
2015 – 2019 | Institut de la Vision – Paris, France
Postdoctoral Researcher | Supervisor: Dr. Deniz Dalkara
Genetic engineering of retinal organoids derived from human induced pluripotent stem cells
Projects
- Generation and characterization of retinal organoids derived from hiPSCs
- Maturation of photoreceptors derived from hiPSCs
- Viral-mediated expression of rod-derived cone viability factor to ameliorate the cones phenotype
- Transplantation of optogenetically-modified photoreceptors derived from hiPSCs in models of retinal degeneration
- Safety profiling of optogenetic tools in retinal organoids derived from hiPSCs
Patents
- 2017 European Patent (EP3516046, n°16 306 225): ‘Optogenetically transformed photoreceptor cells for use in the treatment of retinal degenerative diseases’. Partner Inventor
- 2018 International Patent (WO/2018/055131): ‘Optogenetically transformed photoreceptor cells for use in the treatment of retinal degenerative diseases’. Partner Inventor
Personnel under my supervision:
- Research Assistants
- Laure GUIBBAL, MSc 3 years
- Fiona ROUTET, MSc 3 years
- Lyes TOUALBI, MSc 1 year
- Interns | Bachelor degree
- Karen DAOUD, Sorbonne University. 1.5 months 2015
- Marilyn HARINQUET, Evry University. 2 months 2015
- Interns | Master degree
- Karen DAOUD, Université Paris Descartes. 10.5 months 2017
- Marilyn HARINQUET, Sorbonne University. 4 months 2016
- Fiona ROUTET, Sorbonne University. 6 months 2016
- Parisa KHALILIAN, Sorbonne University. 5 months 2017
- Lyes TOUALBI, Université Paris Saclay. 8 months 2017-18
2009 – 2013 | CABIMER – Seville, Spain
PhD Student and Research Assistant | Supervisor: Dr. Shomi Bhattacharya.
Retinal Degeneration lab, Cell therapy and Regenerative Medicine, Cabimer.
Personnel under my supervision (Research Assitants):
- Andrea Diez Lloret, PhD
- Simone Massalini, MSc
2008 – 2009 | CABIMER – Seville, Spain
Research Assistant | Supervisors: Bernat Soria and Karim Abdelcrim.
Laboratory of Stem Cells.
2005 – 2007 | Instituto de Biomedicina de Sevilla, IBIS – Seville, Spain
MSc. Fellowship | Supervisor Dr. Juan José Toledo-Aral.
Evaluation of the neuroprotective effect of the antioxidant drug NP061017 using the acute Parkinsonism murine model of MPTP
2004 – 2005 | Vivacell Biotechnology/Universidad de Córdoba – Spain
Research Assistant | Supervisor: Dr. Eduardo Muñoz Blanco.
Laboratory of Immunology, Physiology and Cell Biology.
Cytotoxicity Assays in different cell lines. Determination of the biological activity of Cimicifuga racemosa extract.
2002 – 2004 | Universidad de Costa Rica – San José, Costa Rica
Lecturer of Toxicology and Pharmacology, Faculty of Pharmacy
Researcher Centre of Research in Neurosciences | Supervisor: Dr. Jaime Fornaguera Trías.
